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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
4.55
Human Site:
T218
Identified Species:
8.33
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
T218
E
K
I
F
S
E
V
T
P
K
C
E
D
C
Q
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
F173
G
E
S
L
P
A
R
F
F
S
C
M
Q
S
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
S201
N
L
P
A
R
F
F
S
C
M
Q
S
D
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
T218
E
K
I
F
S
E
A
T
P
R
C
E
Q
C
Q
Rat
Rattus norvegicus
Q5RJQ4
350
39301
P204
F
F
G
E
N
L
P
P
R
F
F
S
C
M
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
V232
E
K
I
F
S
S
L
V
P
K
C
D
K
C
Q
Frog
Xenopus laevis
NP_001088636
413
45548
I246
E
K
I
F
S
D
L
I
P
K
C
E
K
C
N
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
I216
N
Q
I
F
S
E
E
I
P
K
C
D
S
C
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
P209
V
F
F
G
E
N
L
P
K
R
F
Y
S
S
P
Honey Bee
Apis mellifera
XP_393038
355
40940
K209
P
Y
T
L
P
W
M
K
E
Q
I
F
K
N
V
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
V284
E
E
V
L
A
M
R
V
A
H
C
K
R
C
E
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
R215
I
M
A
D
L
I
P
R
C
A
K
C
N
E
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
G211
R
E
K
I
T
T
S
G
K
H
P
Q
Q
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
6.6
N.A.
6.6
N.A.
80
6.6
N.A.
N.A.
66.6
66.6
53.3
N.A.
0
0
20
0
P-Site Similarity:
100
13.3
N.A.
13.3
N.A.
86.6
13.3
N.A.
N.A.
80
80
66.6
N.A.
13.3
13.3
53.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
8
8
0
8
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
16
0
54
8
8
47
0
% C
% Asp:
0
0
0
8
0
8
0
0
0
0
0
16
16
0
8
% D
% Glu:
39
24
0
8
8
24
8
0
8
0
0
24
0
8
8
% E
% Phe:
8
16
8
39
0
8
8
8
8
8
16
8
0
8
0
% F
% Gly:
8
0
8
8
0
0
0
8
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% H
% Ile:
8
0
39
8
0
8
0
16
0
0
8
0
0
0
0
% I
% Lys:
0
31
8
0
0
0
0
8
16
31
8
8
24
0
0
% K
% Leu:
0
8
0
24
8
8
24
0
0
0
0
0
0
0
16
% L
% Met:
0
8
0
0
0
8
8
0
0
8
0
8
0
8
0
% M
% Asn:
16
0
0
0
8
8
0
0
0
0
0
0
8
8
8
% N
% Pro:
8
0
8
0
16
0
16
16
39
0
8
0
0
8
8
% P
% Gln:
0
8
0
0
0
0
0
0
0
8
8
8
24
0
31
% Q
% Arg:
8
0
0
0
8
0
16
8
8
16
0
0
8
0
0
% R
% Ser:
0
0
8
0
39
8
8
8
0
8
0
16
16
16
0
% S
% Thr:
0
0
8
0
8
8
0
16
0
0
0
0
0
0
8
% T
% Val:
8
0
8
0
0
0
8
16
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _